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FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22

a domain that carries the phosphorylated histidine residue, His-189

NNMT overexpression has been associated with metabolic dysfunction, obesity, and reduced NAD+ availability